Yeah, it really depends.
Your weight, passenger weight, how far your riding, how often, extra gear.
Due to my fat butt, I had to get some heavy duty shocks. The regular Progressive shocks I had was on the highest setting and it was not enough. My 140 lb daughter would get on and it rode horrible, but nothing I could adjust to make it better.
With the HD shocks, I initially set it on 4. With me alone, it was rough. at 3 it was OK, but with me and my daughter is was decent.
I put it at 2, and was perfect for me alone, and a bit soft for me and my daughter.
I leave it at 2, even with my daughter, unless we are going on a ride longer than 30 minutes , then I go to 4 and it is better. My Progressive shocks are easy to adjust by hand.
For tires, I tend to run pressure a touch higher in front than stock @34-36 PSI (not that your supposed to adjust the front PSI based on weight), and when I had a bike tire on the rear, I also always ran at the higher PSI due to my own weight.
Now that I have a car tire on the back, I don't run it at the "recommended" pressure, I have it set to what rides best, and for me it is 38 PSI, regardless of weight on it.